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**Cara kerja gen resesif** melibatkan interaksi antara alel (bentuk alternatif dari gen) pada lokus (posisi gen pada kromosom) yang sama. Ketika ada alel dominan, alel resesif 'tersembunyi' karena ekspresi fenotip (karakteristik fisik yang terlihat) didikte oleh alel dominan. Namun, ketika seseorang mewarisi dua salinan alel resesif, tidak ada alel dominan untuk menutupi ekspresi gen resesif, sehingga fenotip yang sesuai diekspresikan. Proses ini sangat penting dalam memahami berbagai pola pewarisan, termasuk pewarisan penyakit genetik. Misalnya, penyakit seperti **cystic fibrosis** disebabkan oleh gen resesif. Seseorang harus mewarisi dua salinan gen yang menyebabkan **cystic fibrosis** untuk mengembangkan penyakit tersebut. Jika hanya ada satu salinan, orang tersebut akan menjadi pembawa (carrier) dan tidak menunjukkan gejala, tetapi dapat mewariskan gen tersebut kepada keturunannya. Pemahaman tentang cara kerja gen resesif sangat penting dalam konseling genetik dan membantu dalam memprediksi kemungkinan risiko pewarisan penyakit genetik dalam keluarga.
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