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Targeted therapies are also showing promise. These drugs target specific molecules or pathways involved in cancer cell growth and survival. For example, PARP inhibitors, like olaparib and talazoparib, are approved for patients with TNBC who have a BRCA1 or BRCA2 mutation. PARP inhibitors block the PARP enzyme, which helps cancer cells how old is lecy goranson repair their DNA. By blocking this enzyme, the drugs can cause cancer cells to die. Clinical trials have demonstrated that PARP inhibitors can significantly improve progression-free survival in patients with BRCA-mutated TNBC. Researchers are also exploring other targeted therapies that target different pathways in TNBC cells, such as PI3K/AKT/mTOR and EGFR.
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From that point on, Iran began to actively support various non-state actors and proxy groups, most notably Hezbollah in Lebanon and various Palestinian factions, using them as key instruments to challenge Israeli security and project Iranian influence across the region. These proxy conflicts have been a constant source of friction, often leading to indirect confrontations that teeter on the brink of wider escalation. For Israel, Iran's stated aim to destroy the Jewish state and its actions through proxies represent an existential threat that they take _extremely seriously_. Furthermore, a significant driver of this tension is Iran's **nuclear program**. Israel, along with many Western nations, views Iran's pursuit of nuclear capabilities as an unacceptable danger, fearing that a nuclear-armed Iran would destabilize the entire Middle East and pose an ultimate threat to Israeli security. Iran, on the other hand, insists its nuclear program is for peaceful energy purposes, but its past covert activities and lack of transparency have only intensified international suspicions and Israeli anxieties. The shadow of a nuclear Iran looms large over every discussion about future conflict.