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Memahami **iHER2 negatif** memiliki implikasi yang signifikan dalam perawatan kanker payudara. Pasien dengan HER2 negatif *tidak* akan mendapatkan manfaat dari obat-obatan yang menargetkan HER2, seperti trastuzumab (Herceptin) atau pertuzumab (Perjeta). Obat-obatan ini dirancang untuk mengikat protein HER2 dan menghentikan pertumbuhan sel kanker yang berlebihan. Karena sel kanker pada pasien HER2 negatif tidak memiliki kelebihan protein HER2, obat-obatan ini tidak efektif.
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