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We are going to focus on **ER+/HER2- breast cancer**, which means the cancer cells have receptors for estrogen and don't overexpress the HER2 protein. This is the most common subtype of breast cancer. Systemic therapy is treatment that works throughout the entire body, unlike local treatments like surgery or radiation, which focus on a specific area. The goal of systemic therapy is to eliminate cancer cells, prevent them from spreading, and reduce the risk of the cancer returning. The choice of systemic therapy depends on a bunch of things, including the stage of the cancer, the patient's overall health, and other individual factors. So, what are the main systemic therapies used for ER+/HER2- breast cancer? Well, we have several key players here, and each one plays a vital role. This article will break down each key player.
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